Prevalence of GJB2 and TECTA gene mutations in children with non-syndromic hearing loss visiting an Otorhino-laryngology Hospital in Ho Chi Minh City, Viet Nam

Introduction: Non-syndromic hearing loss (NSHL) in children, which has numerous causes, can impede or even postpone the acquisition of spoken language. In Viet Nam, screening programs and genetic testing for NSHL are rarely applied. this study, 31 pediatric patients had their medical histories collected alongside sequencing results GJB2 TECTA genes to determine prevalence these mutations community associations with potential risk factors. Methods: Information blood samples were from severe-to-profound patients. DNA was extracted, amplified by polymerase chain reaction (PCR), directly sequenced detection (connexin 26) mutations. Results: No gene detected. identified eight (25.8%), three (9.7%) cases heterozygous c.109G>A (V37I), four (12.9%) homozygous one (3.2%) case c.299-300delAT. There no significant between having mutated living urban areas, a family history prelingual deafness, an abnormal obstetric (p > 0.05, Fisher's exact tests). Conclusion: Our study addresses high of GJB2 as causative factors diagnosed at Otorhino-laryngology Hospital Ho Chi Minh City, Nam. Further studies required obtain better understanding spectrum articulate its relationship various